Biochem/physiol Actions
Cell permeable: no
Reversible: no
Target Ki: ~1 nM inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocking in vivo cholesterol synthesis
Primary TargetAMG-CoA reductase
Product does not compete with ATP.
General description
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks in vivo cholesterol synthesis (Ki ~1 nM). Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
A water-soluble, competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that potently blocks in vivo cholesterol synthesis (Ki = ~1 nM). Offers cardioprotection. Also acts as an immunomodulator and an inhibitor of ras p21 isoprenylation.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kwak, B., et al. 2000. Natl. Med.6, 1399.Hamelin, B.A., and Turgeon, J., 1998. Trends Pharmacol. Sci.19, 26.Narisawa, T., et al. 1996. Jpn. J. Cancer Res.87, 798.Cohen, L.H., et al. 1993. Biochem. Pharmacol.45, 2203.Koga, T., et al. 1990. Biochim. Biophys. Acta.1045, 115.Yoshino, G., et al. 1986. Diabetes Res. Clin. Pract. 2, 179
Packaging
Packaged under inert gas
25 mg in Plastic Bag(s)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Warning
Toxicity: Environmental Hazard (N)
This product has met the following criteria to qualify for the following awards: